Your browser doesn't support javascript.
loading
Incompatibility mechanism of Crotonis Semen Pulveratum and Glycyrrhizae Radix et Rhizoma based on diuretic effect and intestinal flora structure / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 518-525, 2019.
Article in Chinese | WPRIM | ID: wpr-777470
ABSTRACT
Based on the toxic characteristics caused by the compatibility between "Zaoji Suiyuan" and Glycyrrhizae Radix et Rhizoma, which was found in the previous studies, the expanded study was carried out on the incompatibility mechanism between Crotonis Semen Pulveratum(CT) and Glycyrrhizae Radix et Rhizoma(GU) with the diuretic effect and intestinal flora as the characteristic indexes. The results showed that GU could slow down the rapid diuretic effect of CT, which suggested a tendency of decreasing the efficacy. Both the high and low dose of CT could significantly induce the intestinal injury and change the intestinal bacteria structure of mice. Low dose CT combined with GU could significantly increase the levels of Streptococcus and Rikenellaceae_ukn. The relative abundance of Desulfovibrio and Streptococcaceae_ukn were increased after the combined application of high dose CT and GU. It also suggested that there was a risk of inflammation in the liver and intestines when combined application of these two herbs. The results revealed that the combination of CT and GU has a tendency to reduce the clinical effect and increase the toxicity from the aspects of its traditional efficacy and its effect on intestinal microflora structure, which could provide the data for the clinical use of CT.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Seeds / Drugs, Chinese Herbal / Chemistry / Plant Roots / Croton / Diuretics / Drug Interactions / Gastrointestinal Microbiome / Glycyrrhiza Limits: Animals Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2019 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Seeds / Drugs, Chinese Herbal / Chemistry / Plant Roots / Croton / Diuretics / Drug Interactions / Gastrointestinal Microbiome / Glycyrrhiza Limits: Animals Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2019 Type: Article