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Study on chemical constituents from fruiting bodies of Ganoderma australe / 中国中药杂志
Article in Chinese | WPRIM | ID: wpr-777474
Responsible library: WPRO
ABSTRACT
Chemical constituents were isolated from the fruiting bodies of Ganoderma australe by various column chromatographic techniques and HPLC method, and their chemical structures were identified through the combined analysis of physicochemical properties and spectral data. Meanwhile, their α-glucosidase inhibitory activity and anti-oxidative ability were evaluated. Seven compounds were isolated from G. australe and were identified as 6-methoxyl-cyclo-(Phe-Ile)(1), applanoxidic acid A methyl ester(2), ergosta-7,22 E-dien-3β-ol(3), cinnamic acid(4), 5α,8α-epidioxy-(20S,22E,24R)-ergosta-6,22-diene-3β-ol(5), 1-(3, 4-dihydroxyphenyl) ethanone(6), salicylic acid(7) and benzoic acid(8). Among the compounds, compound 1 was a new cyclic dipeptide. Compound 2 was a new lanosta natural product, and compounds 4, 6, 7 and 8 were obtained from G. australe for the first time. Moreover, compounds 4 and 8 exhibited α-glucosidase inhibitory activity with inhibition rates of 36.8% and 34.7%, and compounds 4, 7 and 8 had a certain activity in DPPH free radical scavenging activity with IC_(50) values of 0.168, 0.458 and 0.170 g·L~(-1), respectively. The DPPH radical scavenging rate of compound 1 was 41.1%.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Molecular Structure / Chemistry / Free Radical Scavengers / Ganoderma / Fruiting Bodies, Fungal / Glycoside Hydrolase Inhibitors Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Molecular Structure / Chemistry / Free Radical Scavengers / Ganoderma / Fruiting Bodies, Fungal / Glycoside Hydrolase Inhibitors Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2019 Type: Article