Peripheral neuropathy induced by drinking water contaminated with low-dose arsenic in Myanmar
Environmental Health and Preventive Medicine
;
: 23-23, 2019.
Article
in English
| WPRIM
| ID: wpr-777617
ABSTRACT
BACKGROUND@#More than 140 million people drink arsenic-contaminated groundwater. It is unknown how much arsenic exposure is necessary to cause neurological impairment. Here, we evaluate the relationship between neurological impairments and the arsenic concentration in drinking water (ACDW).@*PARTICIPANTS AND METHODS@#A cross-sectional study design was employed. We performed medical examinations of 1867 residents in seven villages in the Thabaung township in Myanmar. Medical examinations consisted of interviews regarding subjective neurological symptoms and objective neurological examinations of sensory disturbances. For subjective neurological symptoms, we ascertained the presence or absence of defects in smell, vision, taste, and hearing; the feeling of weakness; and chronic numbness or pain. For objective sensory disturbances, we examined defects in pain sensation, vibration sensation, and two-point discrimination. We analyzed the relationship between the subjective symptoms, objective sensory disturbances, and ACDW.@*RESULTS@#Residents with ACDW ≥ 10 parts per billion (ppb) had experienced a "feeling of weakness" and "chronic numbness or pain" significantly more often than those with ACDW 50 ppb). These data suggest a threshold for the occurrence of peripheral neuropathy due to arsenic exposure, and indicate that the arsenic concentration in drinking water should be less than 10 ppb to ensure human health.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arsenic
/
Water Pollutants, Chemical
/
Drinking Water
/
Groundwater
/
Chemistry
/
Epidemiology
/
Cross-Sectional Studies
/
Sensation Disorders
/
Myanmar
/
Peripheral Nervous System Diseases
Type of study:
Observational study
/
Prevalence study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Environmental Health and Preventive Medicine
Year:
2019
Type:
Article
Similar
MEDLINE
...
LILACS
LIS