Study progress of the correlation between peri-implantitis, IL-1β, TNF-α and NF-κB signal transduction / 口腔疾病防治
Journal of Prevention and Treatment for Stomatological Diseases
;
(12): 673-676, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-777716
ABSTRACT
@#Increasing numbers of edentulous patients and patients with dental defects are willing to accept implant restorations. However, the development of peri-implantitis is a major factor leading to implant failure. The worsening of peri-implantitis promotes the secretion of inflammatory cytokines such as IL-1β and TNF-α and the gene expression of RANKL, inhibits the gene expression of OPG, and increases osteoclast activity, which promotes bone absorption indirectly and leads to a negative balance in bone metabolism. To gain knowledge about the relationship between peri-implantitis and NF-κB signaling pathways, this article summarizes related reports about peri-implantitis and NF-κB signaling pathways, explores the regulatory mechanism by which peri-implantitis affects bone metabolism and NF-κB signaling, discusses the effect of immunological cytokines on NF-κB signaling pathways when inflammation arises, and provides a theoretical foundation for peri-implantitis research and prevention.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Prevention and Treatment for Stomatological Diseases
Year:
2018
Type:
Article
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