Research progress of pharmacogenetics with wet age-related macular degeneration / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
;
(12): 70-73, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-777799
ABSTRACT
@#Age-related macular degeneration(ARMD)is a multifactorial disease, genetic factors play important roles in the pathogenesis of the disease. To date, intraocular injection of anti-vascular endothelial growth factor drugs is the first choice for the treatment of wet ARMD, but the response is variable. This review summarizes vascular endothelial growth factor(<i>VEGF</i>)gene, complement factor H(<i>CFH</i>)gene, age-related maculopathy susceptibility 2(ARMS2)gene and high-temperature requirement A-1(<i>HTRA1</i>)gene single-nucleotide polymorphisms(SNP)in the study of pharmacological genetics of wet ARMD. It is still worthy of further investigations that the genetic mechanism of the disease, so that we can provide individualized treatment sequences and predict the response to anti-VEGF therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
International Eye Science
Year:
2020
Type:
Article
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