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The Prognostic Significance of the Preoperative Serum CEA, CA19-9 and AFP Levels in Gastric Cancer Patients
Journal of the Korean Surgical Society ; : 302-306, 2008.
Article in Korean | WPRIM | ID: wpr-77802
ABSTRACT

PURPOSE:

No tumor-specific markers for gastric cancer are currently known, although various tumor markers have been utilized. CEA, CA19-9 and AFP are the most commonly used tumor markers for gastric cancer. The aim of this study is to evaluate the prognostic significance of the preoperative CEA, CA19-9 and AFP levels in patients with gastric cancer.

METHODS:

A total of 366 patients who underwent curative surgery for gastric cancer were analyzed. The clinicopathologic characteristics and disease-free survival rate of the patients were compared between the positive and negative CEA, CA19-9 and AFP groups of patients, respectively. Also, the prognostic significance of each tumor marker was assessed by multivariate analysis.

RESULTS:

The CEA, CA19-9 and AFP levels were elevated in 14.2%, 7.9% and 19.1% of the patients, respectively. Serosal invasion and advanced cancer were more frequently found in the groups of patients who were positive for CEA and CA19-9 (P<0.05). More lymph node metastasis and an advanced tumor stage were found in the group of patients who were positive for CA19-9 (P<0.05). On univariate analysis, the disease-free survival rate was significantly lower in the CA19-9 positive group (P<0.05). Serosal invasion and lymph node metastasis were the only significant prognostic factors on multivariate analysis.

CONCLUSION:

CEA, CA19-9 and AFP have proved unhelpful for the early detection of gastric cancer due to the low positive rate. CEA and AFP have no prognostic significance and only CA19-9 can be useful for estimating the severity of gastric cancer and as a limited prognostic factor for gastric cancer patients.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Stomach Neoplasms / Biomarkers, Tumor / Multivariate Analysis / Disease-Free Survival / Lymph Nodes / Neoplasm Metastasis Type of study: Prognostic study / Screening study Limits: Humans Language: Korean Journal: Journal of the Korean Surgical Society Year: 2008 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Stomach Neoplasms / Biomarkers, Tumor / Multivariate Analysis / Disease-Free Survival / Lymph Nodes / Neoplasm Metastasis Type of study: Prognostic study / Screening study Limits: Humans Language: Korean Journal: Journal of the Korean Surgical Society Year: 2008 Type: Article