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Effects of Combined Therapy with Ezetimibe Plus Simvastatin After Drug-Eluting Stent Implantation in a Porcine Coronary Restenosis Model
Journal of Korean Medical Science ; : 716-722, 2010.
Article in English | WPRIM | ID: wpr-77807
ABSTRACT
The aim of this study was to examine the anti-proliferative and anti-inflammatory effects of ezetimibe/simvastatin (E/S) after drug-eluting stent (DES) implantation in a porcine coronary restenosis model. Pigs were randomized into two groups in which the coronary arteries (23 pigs) had DES. Stents were deployed with oversizing (stent/artery ratio 1.31) in porcine coronary arteries. Fifteen pigs were taken 10/20 mg of E/S and eight pigs were not taken E/S. Histopathologic analysis was assessed at 28 days after stenting. In neointima, most inflammatory cells were lymphohistiocytes. Lymphohistiocyte count was not different between two groups (337+/-227 vs. 443+/-366 cells, P=0.292), but neointima area was significantly smaller (1.00+/-0.49 mm2 vs. 1.69+/-0.98 mm2, P=0.021) and percent area stenosis was significantly lower (23.3+/-10% vs. 39+/-19%, P=0.007) in E/S group compared with control group. There were no significant differences in fibrin score (1.99+/-0.79 vs. 1.81+/-0.88, P=0.49), endothelial score (1.75+/-0.66 vs. 1.80+/-0.59, P=0.79), and the percent of endothelium covered lumen (43+/-21% vs. 45+/-21%, P=0.84) between E/S group and control group. Combined therapy with ezetimibe and simvastatin inhibits neointimal hyperplasia, but does not inhibit inflammatory infiltration and arterial healing after DES implantation in a porcine coronary restenosis model.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Swine / Azetidines / Treatment Outcome / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Simvastatin / Coronary Restenosis / Disease Models, Animal / Drug Combinations / Drug Implants / Drug-Eluting Stents Type of study: Controlled clinical trial / Prognostic study Limits: Animals / Female / Humans Language: English Journal: Journal of Korean Medical Science Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Swine / Azetidines / Treatment Outcome / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Simvastatin / Coronary Restenosis / Disease Models, Animal / Drug Combinations / Drug Implants / Drug-Eluting Stents Type of study: Controlled clinical trial / Prognostic study Limits: Animals / Female / Humans Language: English Journal: Journal of Korean Medical Science Year: 2010 Type: Article