Research progress in role of myosin light chain kinase in pathogenesis of nonalcoholic fatty liver disease / 临床肝胆病杂志
Journal of Clinical Hepatology
;
(12): 1156-1159, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-778085
ABSTRACT
Myosin light chain kinase (MLCK) is a key enzyme involved in intestinal mucosal mechanical barrier and plays an important role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). This article describes the "two-hit theory" for NAFLD and gut-derived endotoxin which plays a major role in the pathogenesis of NAFLD, the relationship between endotoxin, MLCK, and NAFLD, and the impact of MLCK inhibitor ML-7 on the intestinal barrier. MLCK inhibitor ML-7 may hinder and delay the development and progression of NAFLD, providing a novel clinical idea for the early prevention of NAFLD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
Language:
Chinese
Journal:
Journal of Clinical Hepatology
Year:
2015
Type:
Article
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