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Efficacy of Tandem High-Dose Chemotherapy and Autologous Stem Cell Rescue in Patients Over 1 Year of Age with Stage 4 Neuroblastoma: The Korean Society of Pediatric Hematology-Oncology Experience Over 6 Years (2000-2005)
Journal of Korean Medical Science ; : 691-697, 2010.
Article in English | WPRIM | ID: wpr-77811
ABSTRACT
The efficacy of tandem high-dose chemotherapy and autologous stem cell rescue (HDCT/ASCR) was investigated in patients with high-risk neuroblastoma. Patients over 1 yr of age who were newly diagnosed with stage 4 neuroblastoma from January 2000 to December 2005 were enrolled in The Korean Society of Pediatric Hematology-Oncology registry. All patients who were assigned to receive HDCT/ASCR at diagnosis were retrospectively analyzed to investigate the efficacy of single or tandem HDCT/ASCR. Seventy and 71 patients were assigned to receive single or tandem HDCT/ASCR at diagnosis. Fifty-seven and 59 patients in the single or tandem HDCT group underwent single or tandem HDCT/ASCR as scheduled. Twenty-four and 38 patients in the single or tandem HDCT group remained event free with a median follow-up of 56 (24-88) months. When the survival rate was analyzed according to intent-to-treat at diagnosis, the probability of the 5-yr event-free survival+/-95% confidence intervals was higher in the tandem HDCT group than in the single HDCT group (51.2+/-12.4% vs. 31.3+/-11.5%, P=0.030). The results of the present study demonstrate that the tandem HDCT/ASCR strategy is significantly better than the single HDCT/ASCR strategy for improved survival in the treatment of high-risk neuroblastoma patients.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Survival Analysis / Prevalence / Survival Rate / Risk Factors / Longitudinal Studies / Treatment Outcome / Combined Modality Therapy / Risk Assessment / Stem Cell Transplantation / Drug Therapy Type of study: Etiology study / Observational study / Prevalence study / Risk factors Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: Asia Language: English Journal: Journal of Korean Medical Science Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Survival Analysis / Prevalence / Survival Rate / Risk Factors / Longitudinal Studies / Treatment Outcome / Combined Modality Therapy / Risk Assessment / Stem Cell Transplantation / Drug Therapy Type of study: Etiology study / Observational study / Prevalence study / Risk factors Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: Asia Language: English Journal: Journal of Korean Medical Science Year: 2010 Type: Article