Progress in immunotherapy and molecular therapy for liver failure / 临床肝胆病杂志
Journal of Clinical Hepatology
;
(12): 1369-1371, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-778121
ABSTRACT
Liver failure is a complex process involving many factors. The molecular therapy targeting the cytokines and receptors associated with liver failure has become the research hotspots in recent years. Immunotherapy for liver failure includes promoting the regeneration of hepatocytes and immunoregulation by thymosin, and the combination of immunomodulatory therapy with traditional therapy is widely applied in clinical treatment. Research on the animal model of liver failure suggested that importing ARC protein or hepatocyte nuclear factor 4 protected hepatocytes and promoted the recovery of their function. Block therapy against liver failure-related molecules (fibrinogen-like protein 2, apoptosis-related molecules, transforming growth factor β, osteopontin, nuclear factor-κB, and Toll-like receptors, etc.) successfully cured the animal model of liver failure. The research on molecular therapy offers a new way for treatment of liver failure, but it is still in the stage of laboratory research at present and lacks clinical data.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Journal of Clinical Hepatology
Year:
2015
Type:
Article
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