Research progress on the role and mechanism of miR-155 in the development of oral squamous cell carcinoma / 口腔疾病防治
Journal of Prevention and Treatment for Stomatological Diseases
;
(12): 809-812, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-778263
ABSTRACT
@#Oral squamous cell carcinoma (OSCC) is the most common oral cancer. Previous studies have found significantly high miR-155 expression in OSCC. However, the mechanism by which miR-155 plays a role in OSCC oncogenesis is not yet clear. This article reviews the function of the relationship between miR-155 and tumors and the potential role of miR-155 in the development of OSCC. A literature review showed that mir-155, as a small carcinogenic RNA, can inhibit CDC73, BCL6, P27Kip1 and other target genes that play a role in cancer inhibition; promote the proliferation, migration and invasion of OSCC cells; and inhibit apoptosis. miR-155 can also be combined with biological factors (Epstein-Barr virus, human papillomavirus) to promote the development of OSCC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Prevention and Treatment for Stomatological Diseases
Year:
2019
Type:
Article
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