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Influence of interaction between endogenous miRNAs and hepatitis B virus in hepatocytes on hepatitis B virus transcription and related mechanisms / 临床肝胆病杂志
Journal of Clinical Hepatology ; (12): 2186-2190, 2016.
Article in Chinese | WPRIM | ID: wpr-778375
ABSTRACT
MicroRNAs (miRNAs) may be involved in the regulation of gene expression after transcription and play important roles in regulating hepatitis B virus (HBV) transcription and replication. This article summarizes the miRNAs with an anti-HBV effect in hepatocytes and 4 regulatory mechanisms, as well as the mechanisms through which HBV affects the expression of endogenous miRNAs in hepatocytes via HBx and self-coding miRNAs and promotes replication. The analyses show that the interaction between endogenous miRNAs and HBV in hepatocytes forms a complex regulatory network, competes for the results of regulation, and determines the activity of HBV transcription and the trend of disease progression. In-depth studies on the mechanisms of the influence of interaction between endogenous miRNA and HBV in hepatocytes on HBV transcription have great significance in exploring new anti-HBV methods.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Clinical Hepatology Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Clinical Hepatology Year: 2016 Type: Article