Clinical value of serum C-reactive protein, procalcitonin, and lipase in predicting severe acute pancreatitis during pregnancy / 临床肝胆病杂志

ABSTRACT

ObjectiveTo investigate clinical value of serum C-reactive protein (CRP), procalcitonin (PCT), and lipase in predicting severe acute pancreatitis (SAP) during pregnancy. MethodsA retrospective analysis was performed for the clinical data of 126 pregnant women with acute pancreatitis (AP) who were treated in Nongken Sanya Hospital from January 2011 to January 2016. According to the severity of AP, the patients were divided into control group (pregnancy complicated by mild-to-moderate AP, 71 patients) and observation group (pregnancy complicated by SAP, 55 patients). The clinical features of AP in pregnancy were compared between the two groups. The laboratory markers including venous leukocyte count, hemoglobin, plasma albumin, blood amylase, CRP, PCT, and lipase were observed. The t-test was used for comparision of continuos data between groups, and the chi-square test was used for comparision of categorial data between groups, and the receiver operating characteristic (ROC) curves were plotted for statistically significant markers to assess their sensitivities and specificities. ResultsThe observation group had significantly higher serum levels of lipase, PCT, and CRP than the control group (lipase 85773±158.61 U/L vs 59019±138.67 U/L, χ2=7.689, P＜0.01; PCT 10.07±4.55 ng/ml vs 5.89±2.13 ng/ml, χ2=15.492, P＜0.01; CRP 269.93±63.61 mg/L vs 202.64±39.58 mg/L, χ2=7.500, P＜0.01). According to the ROC curves, serum lipase, PCT, and CRP had areas under the ROC curve of 0.920, 0.841, and 0.832, respectively, with corresponding cut-off values of 712 U/L, 7.6 ng/ml, and 262.0 mg/L, sensitivities of 87.9%, 83.5%, and 81.3%, and specificities of 83.2%, 86.1%, and 78.9%, respectively. ConclusionIncreased serum levels of lipase, PCT, and CRP have a great value in the diagnosis of SAP during pregnancy.