Risk factors for postoperative pulmonary infection in patients with primary liver cancer / 临床肝胆病杂志

ABSTRACT

ObjectiveTo investigate the risk factors for postoperative pulmonary infection in patients with primary liver cancer through a retrospective analysis, and to provide a reference for appropriate preventive measures in clinical treatment. MethodsA total of 286 patients with liver cancer who visited Department of Hepatology, 180 Hospital of PLA, from May 2011 to December 2015 were enrolled, and according to the presence or absence of postoperative pulmonary infection, these patients were divided into infection group (36 patients) and non-infection group (250 patients). The factors for postoperative pulmonary infection were analyzed. The t-test was used for comparison of continuous data between groups, the chi-square test was used for comparison of categorical data between groups, and logistic multivariate regression analysis was used to analyze the risk factors for postoperative pulmonary infection. ResultsThe univariate analysis showed that age distribution, smoking history, diabetes, intraoperative blood transfusion volume, and the indwelling time of abdominal drainage tube showed significant differences between the two groups (all P＜0.05). The multivariate analysis showed that smoking history, diabetes, intraoperative blood transfusion volume, and the indwelling time of abdominal drainage tube were independent risk factors for postoperative pulmonary infection in patients with primary liver cancer (all P＜0.05). Among the anesthesia-related factors, application of single-use medical devices and perioperative antibacterial agents significantly reduced the incidence rate of postoperative pulmonary infection (both P＜0.05). ConclusionSmoking history, diabetes, intraoperative blood transfusion volume, the indwelling time of abdominal drainage tube, no use of single-use medical devices during anesthesia, and no use of perioperative antibacterial agents are risk factors for postoperative pulmonary infection in patients with primary liver cancer. Corresponding preventative and treatment methods can effectively prevent the development of postoperative pulmonary infection.