Role of ADAMTS13 in diagnosis and pathogenesis of liver diseases / 临床肝胆病杂志
Journal of Clinical Hepatology
;
(12): 390-392, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-778558
ABSTRACT
Recent studies have demonstrated that coagulation function and liver microcirculation disturbance are important in the development and progression of liver diseases. ADAMTS13, also known as von Willebrand factor-cleaving protease, is a metalloproteinase produced by hepatic stellate cells, with major functions to cleave the von Willebrand factor multimers produced by vascular endothelial cells, regulate the adhesive capacity of platelets, and influence the body′s coagulation function and microcirculation. The important role of ADAMTS13 in the pathophysiological processes of various severe liver diseases such as liver cirrhosis, severe alcoholic hepatitis, hepatic veno-occlusive disease after stem cell transplantation, and liver graft dysfunction is reviewed in this paper, and its association with the severity of liver diseases is clarified. Plasma ADAMTS13 is involved in the development and progression of various liver diseases, and measurement of its level and activity can help the diagnosis and differential diagnosis of liver diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
/
Etiology study
Language:
Chinese
Journal:
Journal of Clinical Hepatology
Year:
2016
Type:
Article
Similar
MEDLINE
...
LILACS
LIS