Research advances in susceptibility genes and their role in the pathogenesis of nonalcoholic fatty liver disease / 临床肝胆病杂志

ABSTRACT

Currently the incidence of nonalcoholic fatty liver disease (NAFLD) is increasing, and the age of onset is getting younger worldwide, resulting in a heavy economic burden for both individuals and the society. Since NAFLD is closely related to heredity, metabolism, and the environment, genetic factors play an important role in the development and progression of NAFLD. With the development and wide application of the techniques from the genome-wide association studies, new research advances have been achieved in the susceptibility genes of NAFLD. This review summarizes the related research findings at home and abroad, and investigates the pathogenic factors for NAFLD and related mechanisms with a focus on the polymorphisms of susceptibility genes.