Clinical features of drug-induced liver injury and primary biliary cirrhosis: a comparative analysis / 临床肝胆病杂志

ABSTRACT

ObjectiveTo investigate and compare the clinical features of drug-induced liver injury (DILI) and primary biliary cirrhosis (PBC). MethodsA total of 116 PBC patients and 124 DILI patients who were diagnosed in Shengjing Hospital of China Medical University from January 2005 to December 2013 were enrolled, and clinical features, laboratory indices, and the results of liver biopsy were compared between the two groups. The t-test or Nemenyi rank sum test was applied for comparison of continuous data between the two groups, and the chi-square test was applied for comparison of categorical data between the two groups. ResultsThere were significant differences in age of onset and gender composition between the two groups(both P＜005). The serological markers (except albumin), immunological indicators (IgG, IgM, and IgA), and positive rate of autoantibodies (except SMA) showed significant differences between the two groups (all P＜0.05). The histological appearances of PBC were hepatocyte edema (30 patients), inflammatory cell infiltration around the bile duct (29 patients), and atypical hyperplasia of the small bile duct (28 patients), and those of DILI were hepatocyte steatosis (15 patients) and spotty necrosis and loss of hepatocytes (14 patients). ConclusionDILI and PBC are different in the aspects of laboratory tests and pathological examinations, which has a certain guiding significance in differential diagnosis in clinical practice.