Age and Retinal Nerve Fiber Layer Thickness Measured by Spectral Domain Optical Coherence Tomography
Korean Journal of Ophthalmology
;
: 163-168, 2012.
Article
in English
| WPRIM
| ID: wpr-77873
ABSTRACT
PURPOSE:
To evaluate the association between age and peripapillary retinal nerve fiber layer (RNFL) thickness measured by Cirrus high-definition (HD) spectral domain optical coherence tomography (OCT) in healthy Korean subjects.METHODS:
A total of 302 eyes from 155 healthy Korean subjects (age range, 20 to 79 years) underwent RNFL thickness measurements using the Cirrus HD-OCT. Average, quadrant, and clock-hour RNFL thickness parameters were analyzed in terms of age using linear mixed effect models.RESULTS:
Average RNFL demonstrated a slope of -2.1 microm per decade of age (p < 0.001). In quadrant analysis, superior (-3.4 microm/decade, p < 0.001) and inferior (-2.9 microm/decade, p < 0.001) quadrants showed steeper slopes, whereas temporal (-1.1 microm/decade, p < 0.001) and nasal (-1.0 microm/decade, p < 0.001) quadrants revealed shallower slopes. Among the 12 clock-hour sectors, clock hours 6 (-4.5 microm/decade, p < 0.001) and 1 (-4.1 microm/decade, p < 0.001) showed the greatest tendency to decline with age; RNFLs of the 3 (-0.2 microm/decade, p = 0.391) and 4 (-0.6 microm/decade, p = 0.052) o'clock hour sectors did not show significant decay.CONCLUSIONS:
RNFL thickness was associated with age, especially in superior and inferior areas. The topographic distribution of correlation between age and RNFL thickness was not uniform.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reference Values
/
Retinal Ganglion Cells
/
Aging
/
Reproducibility of Results
/
Tomography, Optical Coherence
/
Asian People
/
Nerve Fibers
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Humans
/
Male
Language:
English
Journal:
Korean Journal of Ophthalmology
Year:
2012
Type:
Article
Similar
MEDLINE
...
LILACS
LIS