Stimulator of interferon genes inhibits the development and progression of chronic liver diseases / 临床肝胆病杂志

ABSTRACT

Stimulator of interferon genes (STING) is an important congenital cytoplasmic cyclic dinucleotide sensor that regulates the internal environment of the liver. It activates IRF3/IRF7 and inhibits the development and progression of chronic liver diseases such as chronic hepatitis B, liver fibrosis, and hepatocellular carcinoma through innate immune response, specific T cell response, and autophagy. This article introduces the distribution, structural characteristics, biological functions, and signaling pathways of STING and its role in the development and progression of chronic liver diseases, in order to elaborate on the role of STING in the intervention of chronic liver diseases and provide new ideas for treatment.