Association of blood lipids and albumin-bilirubin index with disease progression in patients with chronic hepatitis B virus infection / 临床肝胆病杂志

ABSTRACT

ObjectiveTo investigate the value of blood lipid indices and albumin-bilirubin index (ALBI) in evaluating the progression of chronic hepatitis B virus (HBV) infection. MethodsA total of 184 patients with chronic HBV infection who visited The Second Affiliated Hospital of Anhui Medical University from June 2016 to June 2017 were enrolled, and according to the stage of the disease, they were divided into ASC group (74 HBV carriers), CHB group (70 patients with chronic hepatitis B), and LC group (40 patients with compensated cirrhosis). A total of 50 healthy individuals were enrolled as health control (HC) group. Blood lipid indices and liver function parameters were measured, and the changes in blood lipid indices and ALBI during the progression of chronic HBV infection were analyzed. A one-way analysis of variance was used for comparison of continuous data between multiple groups, and the Dunnett method was used for further comparison between two groups; the chi-square test was used for comparison of categorical data between groups; Pearson correlation analysis was used to investigate correlation. Results There were significant differences between the ASC, CHB, LC, and HC groups in blood lipid indices of cholesterol (CHO), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A (APOA), and apolipoprotein B (F=12.075, 19.559, 6.554, 9.392, and 5.458, all P＜0.001), and the LC group had significantly greater reductions in the above indices compared with the other three groups (all P＜0.05). There was a significant difference in ALBI between the four groups (F=49.225, P＜0.001); the LC group had a significantly higher ALBI than the other three groups (all P＜005), and the ASC and CHB groups had a significantly higher ALBI than the HC group (both P＜0.05). CHO, HDL-C, LDL-C, and APOA were negatively correlated with ALBI (all P＜0.05), among which CHO and HDL-C had the strongest correlation with ALBI (r=-0.310 and -0.266, both P＜0.001). ConclusionIn patients with chronic HBV infection, blood lipid indices and ALBI can reflect the degree of liver function damage, especially in patients with liver cirrhosis.