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Function and mechanism of action of the PD-1/PD-L1 pathway in liver diseases / 临床肝胆病杂志
Journal of Clinical Hepatology ; (12): 672-676, 2019.
Article in Chinese | WPRIM | ID: wpr-778876
Responsible library: WPRO
ABSTRACT
Programmed death-1 (PD-1) is an important immunosuppressive molecule which interacts with its ligand programmed death-ligand 1 (PD-L1) and plays an important role in central/peripheral immune tolerance, transplantation immunity, tumor immune escape, and autoimmune disease. At present, there is still no systematic understanding of the role of the PD-1/PD-L1 pathway in the development and progression of liver diseases. This article summarizes related studies on the role of the PD-1/PD-L1 pathway in the progression of liver diseases and reviews the immunoregulatory function of the PD-1/PD-L1 pathway and its role in liver diseases. It is pointed out that the PD-1/PD-L1 pathway is involved in immunoregulatory function of the liver and plays an important role in the development and progression of liver inflammation, autoimmune liver diseases, viral liver diseases, tumor immune escape, transplantation rejection reaction, induced immune response, and autoimmune tolerance. Intervention of the PD-1/PD-L1 pathway may provide new strategies and directions for the prevention and treatment of liver disease.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Clinical Hepatology Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Clinical Hepatology Year: 2019 Type: Article