Advances in the diagnosis and treatment of non-cirrhotic sinusoidal portal hypertension / 临床肝胆病杂志

ABSTRACT

The common causes of non-cirrhotic sinusoidal hypertension were intrahepatic diseases that involves sinusoidal or perisinusoidal space, with sinusoidal obstruction syndrome being a common etiology, which was mainly caused by chemotherapy or radiotherapy prior to hematopoietic stem cell transplantation and pyrrolizidine alkaloid herbal therapy; defibrotide was the only approved drug for this disease. The other causes included nodular regenerative hyperplasia, which were mainly diagnosed by liver pathophysiology; treatment remains largely targeted at the individual sequalae of portal hypertension and respective potential causes.