Research advances in portal hypertension in patients with nonalcoholic fatty liver disease / 临床肝胆病杂志

ABSTRACT

Nonalcoholic fatty liver disease (NAFLD) is often complicated by clinically significant portal hypertension (PHT) during its progression to liver cirrhosis, which is primarily caused by increased intrahepatic vascular resistance. The pathogenesis of PHT in NAFLD remains unclear. This article summarizes the current research status of PHT in NAFLD and related cellular and molecular mechanisms in the development of PHT, in order to provide a theoretical basis for novel preventive and therapeutic strategies for NAFLD.