Advances in prostate-specific membrane antigen-mediated antitumor drugs / 药学学报
Acta Pharmaceutica Sinica
;
(12): 234-2016.
Article
in Chinese
| WPRIM
| ID: wpr-779160
ABSTRACT
Prostate cancer is the most prevalent male malignancy in the United States, and remains the second leading cause of cancer-related death in the male population. Prostate specific membrane antigen (PSMA) is a type of Ⅱ transmembrane glycoproteins that is over-expressed in prostate cancer cell. More importantly, its expression is increased with cancer progression. PSMA has been a major target for imaging and therapeutic applications in prostate cancer. PSMA, also known as N-acetylated α-linked acidic dipeptidase Ⅰ and folate hydrolase, can catalyze the hydrolysis of α-or γ-linked glutamates from peptides or small molecules. This article provides a review of the recent applications of ligand-drug conjugates targeting PSMA and prodrugs activated by PSMA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2016
Type:
Article
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