Hormesis of drugs for infectious diseases / 药学学报
Acta Pharmaceutica Sinica
;
(12): 332-2016.
Article
in Chinese
| WPRIM
| ID: wpr-779173
ABSTRACT
Hormesis, a biphasic dose-response phenomenon characterized by low-dose stimulation and high-dose inhibition, is a common feature of medicines but neglected sometime. Understanding of hormesis is essential for drug discovery and clinical application. Assessing hormetic range needs a proper experiment design including the number of doses and dose spacing, especially in the low dose zone. This article provides the shapes of hormetic dose-response curves, underlying mechanisms and the significance of hormesis for drugs of infectious diseases to facilitate drugs development and clinical applications.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2016
Type:
Article
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