2,3-Dihydro-1H-pyrrolo3,2-cquinoline and 2,3,5,9b-tetrahydro-1Hpyrrolo3,2-c-quinoline derivatives: synthesis and their inhibitory activity against Kv2.1 / 药学学报
Acta Pharmaceutica Sinica
;
(12): 762-2016.
Article
in Chinese
| WPRIM
| ID: wpr-779234
ABSTRACT
Fourteen new compounds with 2,3-dihydro-1H-pyrrolo[3,2-c]-quinoline or 2,3,5,9b-tetrahydro- 1H-pyrrolo[3,2-c]quinoline scaffold were designed and synthesized, and their inhibitory activities against Kv2.1 were evaluated. As a result, 2,3-dihydro-1H-pyrrolo[3,2-c]quinoline derivatives 3a and 5a were identified as potent inhibitors of Kv2.1 with IC50 values of 10.2 and 9.0 μmol·L-1, respectively.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2016
Type:
Article
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