Absorption, distribution, metabolism, excretion and toxicity of biologics and its application in pharmacokinetic modeling / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1202-2016.
Article
in Chinese
| WPRIM
| ID: wpr-779297
ABSTRACT
Recently, more and more attentions of drug development are placed to macromolecules, such as monoclonal antibodies, proteins, etc. It has become one of the most promising areas in drug research and development in 21st Century. In terms of the structure and the ADMET (absorption, distribution, metabolism, excretion and toxicity), macromolecules is different from small molecule drugs, which lead to a distinct modeling strategy. The characterization of biologics ADMET processes and its application in the PK model selection of macromolecules are reviewed in this paper.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2016
Type:
Article
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