rs12252 polymorphism of IFITM3 gene and influenza susceptibility in Chinese population: a study-based sequential Meta-analysis / 中华疾病控制杂志

ABSTRACT

Objective To systematically and quantitatively evaluate the relationship of rs12252 polymorphism in IFITM3 gene and susceptibility to influenza in Chinese population. Methods The databases of Medline, PubMed, Embase, Web of Science, China National knowledge infrastructure (CNKI), Wanfang and VIP were searched to retrieve the articles which focused on the topic of relationship between the rs12252 polymorphism and susceptibility to influenza in Chinese population. Meta-analysis method was used to comprehensively and quantitatively analyze the enrolled articles. Results Seven papers with a total of 919 influenza cases were involved in this article. Influenza virus involved influenza A (H7N9, H1N1 pmd09, H3N2) and influenza B. Study-based sequential meta-analysis of the study showed that the total sample size of this study have achieved the required sample size to obtain stable positive results. The results of this meta-analysis showed that the rs12252 polymorphism was associated with susceptibility to influenza in Chinese population and that the rs12252C polymorphism in IFITM3 gene was more susceptible to have influenza in Chinese people (C vs T OR=1.67, 95% CI1.45-1.92; CC vs TT OR=2.61, 95% CI1.97-3.46; TC vs TT OR= 1.55, 95% CI1.20-2.00; CC vs TC+TT OR= 2.01, 95% CI1.49-2.72; CC+TC vs TT OR =8.90, 95% CI4.94-16.06). Conclusion the rs12252 polymorphism of IFITM3 gene was a risk factor for influenza in Chinese population.