Design, synthesis and biological evaluation of amide derivatives as xanthine oxidase inhibitors / 药学学报
Acta Pharmaceutica Sinica
;
(12): 952-958, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-779680
ABSTRACT
Xanthine oxidase (XO) is a key enzyme in the synthesis of uric acid. Therefore, XO inhibitors play an important role in the antihyperuricemic therapy. Based on the template structures of febuxostat and topiroxostat, 18 amide derivatives were designed and synthesized. Among them, six showed apparent inhibitory activity against XO under the concentration of 10 μmol·L-1. Molecular docking revealed the possible interaction mode of this compound class, which may provide a clue for further molecular design.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2017
Type:
Article
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