Analysis of the Three Dimensional Structure of Envelope Protein of the Japnes Encephalitis virus Isolated in Korea
Journal of the Korean Society of Virology
;
: 209-216, 1997.
Article
in Korean
| WPRIM
| ID: wpr-77978
ABSTRACT
Three dimensional structures of envelope protein from Korean isolates and Nakayama-NIH strain of Japanese encephalitis virus (JEV) were deduced by a computer program (HyperChem 4.0 Chemplus 1.0) based on the data of the three dimentional structure of Tick-borne encephalitis virus. In the three dimensional structure of envelope protein, neutralizing epitope and T-helper cell recognition site of C-terminal region of Korean isolates were structually similar to those of Nakayama-NIH but the N-terminal region was not. Korean JE isolates were compared with Nakayama-NIH strain by using cross-neutralization antibody test. Neutralizing activities of Korean isolates derived from guinea pigs were higher than those of Nakayama-NIH strain against Korean isolates, although the polyclonal antibody titers of Nakayama-NIH showed 1160 to 1640 against Korean isolates. According to the results from three dimentional structures and cross-neutralization analyses, the antigenic difference between Korean JE isolates and Nakayama-NIH strain may be dependent on structural difference of envelope protein.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Encephalitis
/
Encephalitis Virus, Japanese
/
Encephalitis Viruses
/
Encephalitis Viruses, Tick-Borne
/
Guinea Pigs
/
Korea
Limits:
Animals
Country/Region as subject:
Asia
Language:
Korean
Journal:
Journal of the Korean Society of Virology
Year:
1997
Type:
Article
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