Research progress of indoleamine 2,3-dioxygenase 1 in tumor immunotherapy / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1271-1278, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-779997
ABSTRACT
IDO1 (indoleamine 2,3-dioxygenase 1) is one of the most significant checkpoint in tumor immunology. Numerous studies indicates that IDO1 is abnormally expressed in breast cancer, colorectal cancer, liver cancer and other tumor tissues, participating in tumor immune escape through multiple pathways. This review is prepared to elucidate the biological function of IDO1, highlight its pivotal role in tumor evasion, and summarize IDO1 inhibitors in the clinical trials.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2018
Type:
Article
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