The Efficacy and Safety of DA-3030 (Recombinant Human Granulocyte Colony-Stimulating Factor) in Neutropenia after the Remission Induction Chemotherapy in Patients with Acute Myelogenous Leukemia / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 66-68, 2003.
Article
in English
| WPRIM
| ID: wpr-78029
ABSTRACT
PURPOSE:
This study was conducted to determine the efficacy and safety of DA-3030 (a recombinant methionyl human granulocyte colony-stimulating factor, rhG-CSF), after remission induction chemotherapy, in patients with acute myelogenous leukemia (AML). MATERIALS ANDMETHODS:
After the remission induction chemotherapy, with idarubicin (12 mg/m2/day for 3 days) and cytarabine (200 mg/m2/day for 7 days), 26 patients with newly diagnosed AML were assigned to receive DA-3030 (200mug/m2/day), starting 24 hours after the completion of the remission induction chemotherapy, until their neutrophil count recovered to greater than 1, 000/muL for 3 consecutive days.RESULTS:
The median time from the initiation of the chemotherapy to the neutrophil recovery of 1, 000/muL was 21 days (range, 12~41). Treatment with DA-3030 was not associated with significant adverse side effects. The most frequently reported side effects were musculo-skeletal pain (13%) and headache (13%).CONCLUSION:
The DA-3030 is a safe rhG-CSF for the treatment of neutropenia after remission induction chemotherapy in patients with AML.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Remission Induction
/
Idarubicin
/
Leukemia, Myeloid, Acute
/
Granulocyte Colony-Stimulating Factor
/
Cytarabine
/
Drug Therapy
/
Granulocytes
/
Headache
/
Neutropenia
/
Neutrophils
Limits:
Humans
Language:
English
Journal:
Cancer Research and Treatment
Year:
2003
Type:
Article
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