Association of estrogen receptor α gene polymorphisms with hepatitis B cirrhosis / 临床肝胆病杂志

ABSTRACT

At present, hepatitis B cirrhosis still has a major impact on public health and national development. The development and progression of hepatitis B cirrhosis is associated with estrogen. Estrogen acts by binding to estrogen receptors, and the expression and functional status of estrogen receptors are affected by estrogen receptor gene polymorphisms. This article mainly introduces the structure and biological characteristics of estrogen and estrogen receptor α gene and their association with the pathogenesis of hepatitis B cirrhosis, and it is pointed out that the abnormal expression of estrogen may be associated with the development and progression of hepatitis B cirrhosis. However, due to the differences in genetic loci, environment, and location between studies, the results of the association of estrogen receptor α gene polymorphisms with hepatitis B cirrhosis may not be completely consistent.