Correlation studies of specific immune indexes in vitro testing and noninvasive fungalsinusitis / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

Objective:Through the vitro testing of the specific immune globulin, exploring the relationship between the immune index and noninvasive fungal sinusitis, to provide theoretical support for its pathogenesis, subtype classification criterion and perioperative treatment. Method:After retrospectively analyzed 33 patients of NIFS, including FB 16 cases, and AFS 17cases, we got test and analysis of serum specific row of IgE and IgG, total IgE and count of blood eosinophils. Result:①Two groups of patients with eosinophilia positive rate and serum total IgE positive rate have significant differences (χ²=4.661, P<0.05 and χ²=7.127, P<0.01, respectively); ②Total IgE for patients of FB classified mainly in lever 1 (81.25%) and patients of AFS classified mainly in level 2 (41.18%), the difference was statistically significant (Z=-3.189, P<0.01); ③Patients of FB with serum sIgE classified mainly in lever 0 (50%), and patients of AFS mainly in level 2 (47.06%), there was no statistically significant difference between them (Z=-0.655, P>0.05); ④Patients of FB with serum sIgG classified mainly in lever 0 (56.25%), while patients ofAFS mainly at level 1 and 3 (the same 29.41%), there was no statistically significant difference between the two (Z=-1.377, P>0.05). Conclusion:①NIFS pathogenesis is various, not simple for fungal infection causes. Specific allergic constitution NIFS plays an important role in development of pathogenesis; ②In different specific allergic constitution in development of pathogenesis, pathogenic processes of NIFS are different, divided into FB and AFS subtypes; ③Detection of sIgE, sIgG, total IgE, acidophil in the process of sinusitis and nasal polyps can be used as an auxiliary examination, to provide guidance for clinical treatment.