Healing of Injury of Meniscus Using Fibrin Glue and Meniscal Cell in Rabbit Model / 대한정형외과연구학회지
Journal of Korean Orthopaedic Research Society
;
: 265-273, 2003.
Article
in Korean
| WPRIM
| ID: wpr-7812
ABSTRACT
PURPOSE:
We attempt to heal the defect of meniscus using fibrin glue and allogenic meniscal cells in rabbit. MATERIALS ANDMETHODS:
Meniscal cells were isolated from medial meniscus of knee joint of rabbit and cultured and expanded in vitro. The mixture of fibrin glue and meniscal cells implanted to the defect of rabbit meniscus. Examination of gross morphology, histological and immunohistochemical staining of retrieved specimens were performed at 3 and 6 weeks.RESULTS:
Cultured cells uniformly displayed an elongated, fibroblastic and fibrocartilagenous morphology. The histological and immunohistochemical analysis revealed regeneration of meniscal tissue at the defect site.CONCLUSION:
Meniscal cell transplantation with fibrin glue resulted in the regeneration of meniscus tissue successfully in rabbit model. This approach could be applied for treatment of meniscus injury.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Regeneration
/
Menisci, Tibial
/
Fibrin
/
Fibrin Tissue Adhesive
/
Cells, Cultured
/
Cell Transplantation
/
Transplants
/
Fibroblasts
/
Knee Joint
Language:
Korean
Journal:
Journal of Korean Orthopaedic Research Society
Year:
2003
Type:
Article
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