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Three new polyoxygenated bergamotanes from the endophytic fungus Penicillium purpurogenum IMM 003 and their inhibitory activity against pancreatic lipase / 中国天然药物
Article in English | WPRIM | ID: wpr-781222
Responsible library: WPRO
ABSTRACT
Purpurolides D-F (1-3), three new polyoxygenated bergamotanes bearing a 6/4/5/5 tetracyclic ring system, were isolated from the endophytic fungus Penicillium purpurogenum IMM 003. Their structures were unambiguously elucidated based on extensive spectroscopic data analyses, C NMR chemical shifts calculations coupled with the DP4+ probability method, and the calculated and experimental electronic circular dichroism (ECD) spectra. Compounds 1-3 showed significant inhibitory activity against pancreatic lipase (PL). The result highlights that the presence of 3-hydroxylated decanoic acid moiety at C-14 is important for increasing the inhibition potency against PL.

Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2020 Type: Article
Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2020 Type: Article