Association of CHRNA4 gene polymorphisms with response to antidepressant among ethnic Han Chinese / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 1230-1234, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-781309
ABSTRACT
OBJECTIVE@#To assess the association of single nucleotide polymorphisms (SNPs) CHRNA4 gene with response to selective serotonin re-uptake inhibitors (SSRIs) for the treatment of major depressive disorder (MDD).@*METHODS@#For 304 patients receiving drug treatment for major depression, 2 SNPs, namely rs4522666 and rs4603829, of the CHRNA4 gene were determined by matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) mass spectrometry. HAMD-17 was adopted as the primary rating tool to evaluate the severity of depression on the baseline and at the end of 1st, 2nd, 4th and 6th weeks treatment.@*RESULTS@#The frequency of GG genotype/G allele for rs4522666 differed significantly from that of TT and GT genotypes/T allele between responders and non-responders (P=0.015 and P=0.006, respectively). No significant difference was found in genotypic and allelic frequencies of rs4603829 between the two groups (P> 0.05).@*CONCLUSION@#SNPs of the CHRNA4 gene may play an important role in the response to antidepressant drugs among ethnic Han Chinese with MDD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
China
/
Receptors, Nicotinic
/
Polymorphism, Single Nucleotide
/
Asian People
/
Depressive Disorder, Major
/
Drug Therapy
/
Gene Frequency
/
Genetics
/
Genotype
Limits:
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2019
Type:
Article
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