Expression and Clinical Significance of Serum LRG1 in Patients with Diffuse Large B-Cell Lymphoma before Treatment / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1850-1855, 2019.
Article
in Zh
| WPRIM
| ID: wpr-781529
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the clinical significance of serum LRG1, LDH and β2-MG in the recurrence of diffuse large B-cell lymphoma(DLBCL) after chemotherapy.@*METHODS@#The serum levels of LRG1, LDH and β2-MG of 80 patients with DLBCL were detected before treatment and followed up for these patients was performed. The cut-off value of non-recurrent survival was determined by ROC analysis. The correlation of three serum markers for predicting recurrence with prognostic factors of diffuse large B-cell lymphoma patients after treatment was analyzed by ROC curve.@*RESULTS@#The serum levels of LDH, LRG1 and β2-MG were higher in the groups with high tumor stageing, extranodal invasion and bone marrow involvement, respectively(P<0.05). The optimal cut-off values for predicting recurrence risk determined by ROC analysis: LDH 402.37 U/L, LRG1 1.81 mg/L and β2-MG 168.3 ng/L, respectively.COX multivariate regression analysis showed that serum LRG1 was an independent factor affecting the recurrence of diffuse large B-cell lymphoma(P<0.05).@*CONCLUSION@#The serum level of LRG1 may become a new biological marker to predict the recurrence risk of diffuse large B-cell lymphoma.
Full text:
1
Index:
WPRIM
Main subject:
Prognosis
/
Glycoproteins
/
Antineoplastic Combined Chemotherapy Protocols
/
Retrospective Studies
/
Lymphoma, Large B-Cell, Diffuse
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Neoplasm Recurrence, Local
Type of study:
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2019
Type:
Article