Applications of engineered intestinal bacteria in disease diagnosis and treatment / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 2350-2366, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-781633
ABSTRACT
Intestinal bacteria interact closely with human health and diseases. With the development of high-throughput sequencing technologies, researchers have discovered the potential of intestinal bacteria in the diagnosis and treatment of diseases. Meanwhile, synthetic biology strategies are applied to engineer these bacteria for clinical applications. These engineered intestinal microbial are constructed by designing editing tools and feedback loops to gain functions of diagnose or targeted therapy. Consequently, these engineered bacteria are capable of sensing, calculating and responding to the environment. In this review, we summarize the recent advances in engineered intestinal bacteria in disease diagnosis and treatment. Furthermore, we also discuss the current status and future prospect of the engineered intestinal bacteria regarding their clinical applications, market, and safety issues.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bacteria
/
High-Throughput Nucleotide Sequencing
/
Synthetic Biology
Type of study:
Diagnostic study
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2019
Type:
Article
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