N-methyl-D-aspartate Receptor:Potential Role in TreatingNeuraxial Opioid Induced Pruritus / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 851-856, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-781649
ABSTRACT
Neuraxial opioid administration is one of the most common methods of anesthesia and analgesia,while itching is the most troublesome adverse effect.The current treatments for neuraxial opioid-induced pruritus still have certain limitations.This article reviews the current treatments and basic scientific findings(including neurotransmitters,opioid receptors,and signaling pathways)of pruritus caused by neuraxial opioids.Based on our recent findings on N-methyl-D-aspartate(NMDA)receptors and pruritus caused by neuraxial opioids,we provide new ideas for the treatment of itching caused by neuraxial opioids.Since NMDA receptors may play a key role in neuraxial opioid-induced pruritus,NMDA receptor antagonists can have certain therapeutic advantages.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pruritus
/
Receptors, N-Methyl-D-Aspartate
/
Analgesics, Opioid
Limits:
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2019
Type:
Article
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