Increased Progastrin-Releasing Peptide Expression is Associated with Progression in Gastric Cancer Patients
Yonsei Medical Journal
;
: 15-19, 2020.
Article
in English
| WPRIM
| ID: wpr-782128
ABSTRACT
PURPOSE: The purpose of this study was to assess the diagnostic and prognostic value of serum progastrin-releasing peptide (ProGRP) in patients with gastric cancer (GC).MATERIALS AND METHODS:
A total of 150 patients with GC (89 males and 61 females) were recruited, including those with stage I (n=28), stage II (n=33), stage III (n=50), and stage IV (n=39) disease; 50 healthy controls and 66 patients with benign gastric diseases were also enrolled. Levels of serum ProGRP, carcinoembryonic antigen (CEA), and carbohydrate antigen 72-4 (CA72-4) were measured in all subjects.RESULTS:
Serum ProGRP levels were significantly higher in GC patients than in controls (p<0.001), and ProGRP was significantly correlated with tumor size, tumor node metastasis stage, differentiation, invasion depth, and lymph node metastasis (p< 0.005). ProGRP levels were significantly decreased after chemotherapy (p<0.001). Receiver operating characteristic curves revealed a sensitivity and specificity for serum ProGRP in GC of 85.9% and 81.2%, respectively. ProGRP levels were positively correlated with CA72-4 and CEA (r=0.792 and 0.688, p<0.05, respectively). Combined detection of ProGRP, CEA, and CA72-4 showed the best diagnostic power for GC.CONCLUSION:
ProGRP may be useful as a potential biomarker for GC diagnosis and therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stomach Diseases
/
Stomach Neoplasms
/
Carcinoembryonic Antigen
/
ROC Curve
/
Sensitivity and Specificity
/
Diagnosis
/
Drug Therapy
/
Lymph Nodes
/
Neoplasm Metastasis
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
/
Male
Language:
English
Journal:
Yonsei Medical Journal
Year:
2020
Type:
Article
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