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NOTCH1 Pathway is Involved in Polyhexamethylene Guanidine-Induced Humidifier Disinfectant Lung Injuries
Eun LEE; Mi-Jin KANG; Jeong-Hyun KIM; Seung-Hwa LEE; So-Yeon LEE; Hyun-Ju CHO; Jisun YOON; Sungsu JUNG; Yangsoon PARK; Dong-Kyu OH; Sang-Bum HONG; Soo-Jong HONG.
Yonsei Medical Journal ; : 186-191, 2020.
Article in English | WPRIM | ID: wpr-782192
ABSTRACT
0.2 and p<0.05. NOTCH1 was identified as a candidate network hub gene in cases. NOTCH1 transcripts significantly increased in lung tissues from HDLI cases compared to unexposed controls (p=0.05). NOTCH1 may play an important role in pulmonary fibrosis of HDLI.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pulmonary Fibrosis / DNA Methylation / Gene Expression Profiling / Lung Injury / Humidifiers / Korea / Lung / Methylation Limits: Child / Humans Country/Region as subject: Asia Language: English Journal: Yonsei Medical Journal Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pulmonary Fibrosis / DNA Methylation / Gene Expression Profiling / Lung Injury / Humidifiers / Korea / Lung / Methylation Limits: Child / Humans Country/Region as subject: Asia Language: English Journal: Yonsei Medical Journal Year: 2020 Type: Article