Performance Evaluation of the CS-5100 Coagulation Analyzer for Special Coagulation Parameters
Laboratory Medicine Online
;
: 25-32, 2020.
Article
in English
| WPRIM
| ID: wpr-782251
ABSTRACT
BACKGROUND: The CS-5100 high-throughput automated coagulometer (Sysmex, Japan) can perform general and special coagulation assays. We evaluated the performance of the CS-5100 coagulometer to measure fibrinogen degradation product (FDP), plasma level of unfractionated heparin (UFH), low molecular weight heparin (LMWH), and direct oral anticoagulants (DOACs).METHODS:
Precision, linearity, and carryover rate of the CS-5100 while measuring FDP, UFH, and LMWH were validated. Precision and linearity were validated for measurements of DOACs. Results of FDP measurement using CS-5100 were compared to those using the currently used STA-R coagulometer (Diagnostica Stago, France). The reference range of FDP was established. All evaluation procedures were in accordance with Clinical and Laboratory Standards Institute guidelines.RESULTS:
CS-5100 displayed good precision, linearity, and carryover rate for measuring FDP, UFH, LMWH, and DOACs. The FDP level measured with the CS-5100 and STA-R coagulometers correlated well. The reference range of FDP with CS-5100 was 0.0 to 3.48 µg/mL.CONCLUSIONS:
The CS-5100 coagulometer has acceptable analytical performance in measuring special coagulation parameters. It is suitable for the reliable measurement of plasma FDP and anticoagulant levels in clinical laboratories.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Reference Values
/
Fibrinogen
/
Heparin
/
Heparin, Low-Molecular-Weight
/
Anticoagulants
Type of study:
Practice guideline
Language:
English
Journal:
Laboratory Medicine Online
Year:
2020
Type:
Article
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