Involvement of the TNF-α Pathway in TKI Resistance and Suggestion of TNFR1 as a Predictive Biomarker for TKI Responsiveness in Clear Cell Renal Cell Carcinoma
Journal of Korean Medical Science
;
: 31-2020.
Article
in English
| WPRIM
| ID: wpr-782505
ABSTRACT
10% of labeled tumor cells) of TNF receptor 1 (TNFR1), the protein product of TNFRSF1A gene, was correlated with sarcomatoid dedifferentiation and was an independent predictive factor of clinically unfavorable response and shorter survivals in separated TKI-treated ccRCC cohort.CONCLUSION:
TNF-α signaling may play a role in TKI resistance, and TNFR1 expression may serve as a predictive biomarker for clinically unfavorable TKI responses in ccRCC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protein-Tyrosine Kinases
/
Drug Resistance
/
Immunohistochemistry
/
Carcinoma, Renal Cell
/
Biomarkers
/
Gene Expression
/
Cohort Studies
/
Tumor Necrosis Factor-alpha
/
Receptors, Tumor Necrosis Factor
/
Gene Expression Profiling
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2020
Type:
Article
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