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Attenuated total reflection Fourier transform infrared as a primary screening method for cancer in canine serum
Journal of Veterinary Science ; : 16-2020.
Article in English | WPRIM | ID: wpr-782510
ABSTRACT
Cancer is a major cause of death in dogs worldwide, and the incidence of cancer in dogs is increasing. The attenuated total reflection Fourier transform infrared spectroscopic (ATR-FTIR) technique is a powerful tool for the diagnosis of several diseases. This method enables samples to be examined directly without pre-preparation. In this study, we evaluated the diagnostic value of ATR-FTIR for the detection of cancer in dogs. Cancer-bearing dogs (n = 30) diagnosed by pathologists and clinically healthy dogs (n = 40) were enrolled in this study. Peripheral blood was collected for clinicopathological diagnosis. ATR-FTIR spectra were acquired, and principal component analysis was performed on the full wave number spectra (4,000–650 cm−1). The leave-one-out cross validation technique and partial least squares regression analysis were used to predict normal and cancer spectra. Red blood cell counts, hemoglobin levels and white blood cell counts were significantly lower in cancer-bearing dogs than in clinically healthy dogs (p < 0.01, p < 0.01 and p = 0.03, respectively). ATR-FTIR spectra showed significant differences between the clinically healthy and cancer-bearing groups. This finding demonstrates that ATR-FTIR can be applied as a screening technique to distinguish between cancer-bearing dogs and healthy dogs.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Least-Squares Analysis / Mass Screening / Incidence / Cause of Death / Principal Component Analysis / Diagnosis / Erythrocyte Count / Fourier Analysis / Leukocyte Count / Methods Type of study: Diagnostic study / Incidence study / Prognostic study / Screening study Limits: Animals Language: English Journal: Journal of Veterinary Science Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Least-Squares Analysis / Mass Screening / Incidence / Cause of Death / Principal Component Analysis / Diagnosis / Erythrocyte Count / Fourier Analysis / Leukocyte Count / Methods Type of study: Diagnostic study / Incidence study / Prognostic study / Screening study Limits: Animals Language: English Journal: Journal of Veterinary Science Year: 2020 Type: Article