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Assessment of neovascularization during bone healing using contrast-enhanced ultrasonography in a canine tibial osteotomy model: a preliminary study
Journal of Veterinary Science ; : 10-2020.
Article in English | WPRIM | ID: wpr-782515
ABSTRACT
Blood perfusion of skeletal muscle and callus was evaluated using contrast-enhanced ultrasonography (CEUS) in a canine osteotomy model to determine the applicability of CEUS in the assessment of neovascularization during fracture healing and to compare the vascular signals on CEUS between external skeletal fixation and cast-applied dogs. In 6 Beagle dogs, a simple transverse osteotomy was performed at the left tibial shaft and external skeletal fixation (n = 3) or a cast (n = 3) was applied. Radiography, power Doppler ultrasonography (power Doppler), and CEUS were performed until complete union was achieved. On CEUS, vascular changes were quantitatively evaluated by measuring peak intensity (PI) and time to PI in the soft tissue and callus and by counting the vascular signals. Vascular signals from the soft tissue were detected on power Doppler and CEUS on day 2. Significantly more vascular signals were detected by CEUS than by power Doppler. On CEUS, PI in the surrounding soft tissue was markedly increased after the fracture line appeared indistinctively changed on radiography in all dogs. In the cast-applied dogs, vascular signals from the periosteal and endosteal callus were detected on CEUS before mineralized callus was observed on radiography. CEUS was useful in assessing the vascularity of soft tissue and callus, particularly in indirect fracture healing, and provided indications of a normally healing fracture.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Osteotomy / Perfusion / Bony Callus / Diagnostic Imaging / Radiography / Ultrasonography / Fracture Healing / Ultrasonography, Doppler / Muscle, Skeletal / Microbubbles Type of study: Diagnostic study Limits: Animals Language: English Journal: Journal of Veterinary Science Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Osteotomy / Perfusion / Bony Callus / Diagnostic Imaging / Radiography / Ultrasonography / Fracture Healing / Ultrasonography, Doppler / Muscle, Skeletal / Microbubbles Type of study: Diagnostic study Limits: Animals Language: English Journal: Journal of Veterinary Science Year: 2020 Type: Article