An Association Study of Polymorphisms in JAK3 Gene with Lung Cancer in the Korean Population / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 108-116, 2011.
Article
in English
| WPRIM
| ID: wpr-78353
ABSTRACT
PURPOSE:
The genetic alteration of the janus kinases (JAKs), non-receptor tyrosine kinase, is related to the development of human cancers. However, little is known about how the sequence variation of JAK3 contributes to the development of lung cancer. This study investigated whether polymorphisms at the promoter region of the JAK3 gene are associated with the risk of lung cancer in the Korean population. MATERIALS ANDMETHODS:
A total of 819 subjects, including 409 lung cancer patients and 410 healthy controls were recruited. The SNaPshot assay and polymerase chain reaction-restriction fragment length polymorphism analysis were used, and logistic regression analyses were performed to characterize the association between polymorphisms of JAK3 and lung cancer risk.RESULTS:
Three polymorphisms (-672 G>A, +64 A>G and +227 G>A) of JAK3 were analyzed for large-scale genotyping (n=819). Statistical analyses revealed that polymorphisms and haplotypes in the JAK3 gene were not significantly associated with lung cancer.CONCLUSION:
JAK3 gene was not significantly associated with the risk of lung cancer in the Korean population.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Haplotypes
/
Protein-Tyrosine Kinases
/
Logistic Models
/
Promoter Regions, Genetic
/
Janus Kinases
/
Janus Kinase 3
/
Korea
/
Lung
/
Lung Neoplasms
Type of study:
Risk factors
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Cancer Research and Treatment
Year:
2011
Type:
Article
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