Your browser doesn't support javascript.
loading
Comparison of Clinical Outcomes of Hydrophilic and Lipophilic Statins in Patients with Acute Myocardial Infarction
The Korean Journal of Internal Medicine ; : 294-303, 2011.
Article in English | WPRIM | ID: wpr-78394
ABSTRACT
BACKGROUND/

AIMS:

A controversy exists about which statin is preferable for patients with acute myocardial infarction (AMI), and clinical impacts of different statins according to lipophilicity have not been established.

METHODS:

The 1,124 patients with AMI included in the present study were divided into hydrophilic- and lipophilic-statin groups. In-hospital complications (defined as death, cardiogenic shock, ventricular arrhythmia, infection, bleeding, and renal insufficiency, and other fatal arrhythmias), major adverse cardiac events (MACE), all-cause death, re-myocardial infarction, re-percutaneous coronary intervention (re-PCI), and surgical revascularization were analyzed during a 1-year clinical follow-up.

RESULTS:

Baseline characteristics were similar between the two groups, and in-hospital complication rates showed no between-group differences (11.7% vs. 12.8%, p = 0.688). Although MACE at the 1- and 6-month clinical follow-ups occurred more in hydrophilic statin group I (1 month 10.0% vs. 4.4%, p = 0.001; 6 month 19.9% vs. 14.2%, p = 0.022), no significant difference in MACE was observed at the 1-year follow-up (21.5% vs. 17.9%, p = 0.172). Both statin groups showed similar efficacy for reducing serum lipid concentrations. A Cox-regression analysis showed that the use of a hydrophilic statin did not predict 1-year MACE, all-cause death, AMI, or re-PCI.

CONCLUSIONS:

Although short-term cardiovascular outcomes were better in the lipophilic-statin group, 1-year outcomes were similar in patients with AMI who were administered hydrophilic and lipophilic statins. In other words, the type of statin did not influence 1-year outcomes in patients with AMI.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Recurrence / Time Factors / Biomarkers / Cardiovascular Diseases / Chi-Square Distribution / Proportional Hazards Models / Retrospective Studies / Risk Factors / Treatment Outcome / Hospital Mortality Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: The Korean Journal of Internal Medicine Year: 2011 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Recurrence / Time Factors / Biomarkers / Cardiovascular Diseases / Chi-Square Distribution / Proportional Hazards Models / Retrospective Studies / Risk Factors / Treatment Outcome / Hospital Mortality Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: The Korean Journal of Internal Medicine Year: 2011 Type: Article