Insulin Resistance as a Risk Factor for Gallbladder Stone Formation in Korean Postmenopausal Women
The Korean Journal of Internal Medicine
;
: 285-293, 2011.
Article
in English
| WPRIM
| ID: wpr-78395
ABSTRACT
BACKGROUND/AIMS:
The objective of this study was to determine whether insulin resistance is associated with gallbladder stone formation in Korean women based on menopausal status.METHODS:
The study included 4,125 consecutive Korean subjects (30-79 years of age). Subjects who had a medical history of diabetes, hypertension, dyslipidemia, other cardiovascular disorders, or hormone replacement therapy were excluded. The women were subdivided into two groups according to their menopausal status.RESULTS:
Analysis of premenopausal women showed no significant differences in the homeostasis model of assessment-insulin resistance (HOMA-IR) index between the two groups in terms of gallstone disease. The associations between the occurrence of gallbladder stones and age, obesity, abdominal obesity, hyperinsulinemia, and high HOMA-IR index were statistically significant in the analysis with postmenopausal women. In a multiple logistic regression analysis, low high density lipoprotein-cholesterol was an independent predictor of gallbladder stone formation in premenopausal women. However, the multiple logistic regression analysis also showed that age and HOMA-IR were significantly associated with gallbladder stone formation in postmenopausal women. In an additional analysis stratified by obesity, insulin resistance was a significant risk factor for gallbladder stone formation only in the abdominally obese premenopausal group.CONCLUSIONS:
Insulin resistance may be associated with gallbladder stone formation in Korean postmenopausal women with abdominal obesity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Insulin Resistance
/
Gallstones
/
Chi-Square Distribution
/
Logistic Models
/
Odds Ratio
/
Surveys and Questionnaires
/
Risk Factors
/
Age Factors
/
Postmenopause
/
Risk Assessment
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Female
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2011
Type:
Article
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