Evaluation of Effect-site Concentration of Remifentanil for Blunting Hemodynamic Responses to Endotracheal Intubation during Total Intravenous Anesthesia using Propofol / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 269-274, 2007.
Article
in Korean
| WPRIM
| ID: wpr-78427
ABSTRACT
BACKGROUND:
The present study was undertaken to determine the effect-site concentration of remifentanil for blunting hemodynamic responses to tracheal intubation during total intravenous anesthesia (TIVA) using propofol.METHODS:
In this prospective, randomized, double-blind study, a total of 126 patients, aged 18-60 (ASA I or II), having undergone elective surgery under TIVA using propofol were investigated. Anesthesia was induced using propofol (target effect-site concentration 4microgram/ml) and rocuronium (0.9 mg/kg). Remifentanil was infused at target effect-site concentrations of 0, 2, 4, 6 ng/ml groups R1, R2, R3 and R4, respectively. The systolic arterial pressure (SAP), diastolic arterial pressure (DAP) and heart rate (HR) were measured pre-induction, and before and after tracheal intubation.RESULTS:
After intubation, the SAP, DAP and HR increased significantly (P < 0.05) in all groups compared to the pre-intubation values. Compared with pre-induction values, the SAP and DAP in groups R1 and R2 increased significantly after intubation (P < 0.05), but those in group R3 remained constant until 1 min after intubation. The SAP and DAP in group 4 however, decreased significantly (P < 0.05) for 3 min after intubation. The HR increased significantly after intubation in groups R1, R2 and R3 compared to the values before intubation (P < 0.05), but that in group R4 being remained constant.CONCLUSIONS:
We suggest that the optimal target effect-site concentrations of remifentanil for blunting hemodynamic responses to tracheal intubation were 4 or 6 ng/ml during TIVA using propofol.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Propofol
/
Double-Blind Method
/
Prospective Studies
/
Arterial Pressure
/
Heart Rate
/
Hemodynamics
/
Intubation
/
Intubation, Intratracheal
/
Anesthesia
/
Anesthesia, Intravenous
Type of study:
Controlled clinical trial
/
Observational study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2007
Type:
Article
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